Delta-8-THC is a minor cannabinoid, occurring in the plant in very small concentrations. Delta-8-THC is also known to be a degraded form of THC, and is not directly produced by cannabinoid-synthesizing enzymes within the plant. When THC is stored for a period of time, it degrades into delta-8-THC. Commercial growers and extractors use selective breeding and molecular isolation to access greater quantities of delta-8-THC.

“When I vape delta-8-THC, I notice that it stimulates my appetite.”

“I’ve been told that delta-8-THC gives a smooth high with no anxiety or paranoia.”

What is Delta-8-THC?

Delta-8-THC is distinct from the THC that is often mentioned in conversation about cannabis. What we refer to as THC usually means delta-9-THC, the main form of THC found in cannabis. Delta-8-THC  is an analog of delta-9-THC, a molecule with a similar structure, but some notable differences. While the two share many similar properties, such as reportedly stimulating appetite, reducing nausea, and soothing pain, delta-8-THC tends to exhibit a lower psychotropic potency than delta-9-THC.

What is Delta-8-THC and What is Its Place Among the Other Cannabinoids?

There are more than 100 cannabinoids present in the cannabis plant. While we have some foundational knowledge about the primary cannabinoids, delta-9-THC and cannabidiol (CBD), we know less about the secondary, or minor, cannabinoids.

Delta-8-THC is a minor cannabinoid, occurring in the plant in very small concentrations. Delta-8-THC is also known to be a degraded form of THC, and is not directly produced by cannabinoid-synthesizing enzymes within the plant. When THC is stored for a period of time, it degrades into delta-8-THC. Commercial growers and extractors use selective breeding and molecular isolation to access greater quantities of delta-8-THC.

How Does Delta-8-THC Work with the Endocannabinoid System?

Delta-8-THC binds to the CB1 receptors located in the central nervous system. Delta-8-THC additionally has an affinity for CB2 receptors, although less is known about this binding mechanism.

Mechanism of Action

Delta-8-THC binds to the CB1 receptor like delta-9-THC, but its affinity for the receptor is different due to its slightly altered molecular structure. The CB1 receptor is responsible for mediating most of the psychotropic effects of THC.

This differential binding may be responsible for the reported clearer high with reduced anxiety, and greater ability to concentrate often associated with delta-8-THC. It’s possible that its unique molecular structure also impacts the chemical’s effects on other receptors and neural pathways.

Entourage/Ensemble Effect

The entourage or ensemble effect is the principle that the THC molecule works better when taken in conjunction with the array of other cannabinoids, terpenoids, flavonoids, and compounds present in cannabis, rather than as an isolated molecule. This enhancement can create preferable therapeutic outcomes compared to isolated THC. While the knowledge we have about the entourage effect is based on delta-9-THC, the molecular similarity of delta-8-THC could mean that it produces enhanced effects when ingested as whole-plant medicine rather than as an isolate.

More research is needed, however, to gain detailed insights into the ensemble effects of delta-8-THC, and whether its presence helps to mediate the effects of other cannabinoids.

Delta 8 Gummies Potential

A range of preclinical and clinical studies are uncovering some of the unique properties and therapeutic potential of delta-8-THC.

Pain and Anti-Inflammatory Effects

A 2018 preclinical study published in “Cannabis and Cannabinoid Research” found that delta-8-THC may help to diminish pain and inflammation in corneal injury in mice. The research found that delta-8-THC, applied topically, assisted in pain reduction, and reduced inflammation through its effects on the CB1 receptors. Another preclinical study on rats also reported that delta-8-THC delivers pain relief, but that tolerance to the cannabinoid developed rapidly.

Anxiety

According to the U.S. National Library of Medicine, delta-8-THC displays anxiety-reducing qualities similar to delta-9-THC. While there is currently little clinical literature investigating its anti-anxiety potential, anecdotal reports claim that the consumption of delta-8-THC results in a very calm, focused high, without the anxiety that can sometimes accompany delta-9-THC.